90plus 纳米粒度仪应用案例-22
文献名：polymer-surfactantnanoparticlesforsustainedreleaseofwater-solubledrugs
作者：maheshd.chavanpatil,1aymankhdair,1yogeshpatil,1hiteshhanda,2guangzhaomao,2jayanthpanyam1,3
1departmentofpharmaceuticalsciences,eugeneapplebaumcollegeofpharmacyandhealthsciences,waynestateuniversity,detroit,mi48201
2departmentofchemicalengineeringandmaterialsscience,collegeofengineering,waynestateuniversity,detroit,mi48202
3karmanoscancerinstitute,detroit,mi48201
摘要：poordrugencapsulationefficiencyandrapidreleaseoftheencapsulateddruglimittheuseofnanoparticlesinbiomedicalapplicationsinvolvingwater-solubledrugs.wehavedevelopedanovelpolymer-surfactantnanoparticleformulation,usingtheanionicsurfactantaerosolottm(aot)andpolysaccharidepolymeralginate,forsustainedreleaseofwater-solubledrugs.particlesizeofnanoparticles,asdeterminedbyatomicforcemicroscopyandtransmissionelectronmicroscopy,wasintherangeof40–70nm.weaklybasicmoleculeslikemethyleneblue,doxorubicin,rhodamine,verapamil,andclonidinecouldbeencapsulatedefficientlyinaot-alginatenanoparticles.invitroreleasestudieswithbasicdrugmoleculesindicatethatnanoparticlesreleased60–70%oftheencapsulateddrugover4weeks,withnearzero-orderreleaseduringthefirst15days.studieswithanionicdrugmoleculesdemonstratepoorerdrugencapsulationefficiencyandmorerapiddrugreleasethanthoseobservedwithbasicdrugs.furtherstudiesinvestigatingtheeffectofsodiumconcentrationinthereleasemediumandthechargeofthedrugsuggestthatcalcium-sodiumexchangebetweennanoparticlematrixandreleasemediumandelectrostaticinteractionbetweendrugandnanoparticlematrixareimportantdeterminantsofdrugrelease.inconclusion,wehaveformulatedanovelsurfactantpolymerdrugdeliverycarrierdemonstratingsustainedreleaseofwater-solubledrugs.
关键词：alginate;drugdelivery;controlledrelease;nanoparticles;polyelectrolytes;surfactants
武汉到河间货运专线直达物流_武汉到河间物流公司
湛江到无锡滨湖区物流专线_湛江到滨湖区物流公司直达运输
优质巢湖到上海杨浦区物流公司,专业巢湖到杨浦区物流专线
彭州到中山货运专线家具运输_彭州到中山物流公司
南京到济南市中区专线物流公司[省心派送]_南京到市中区专线货运
90plus 纳米粒度仪应用案例-22
南京到上海松江区货运公司,南京到松江区物流专线返程车货运
无锡滨湖区到北京东城区专线物流货运_无锡滨湖区到东城区物流专线运输公司
专业金华到当雄县物流公司,金华到西藏当雄县物流专线运输
常州到西宁货运公司,常州到西宁物流专线回程车货运
如皋到中山货运专线物流直达_如皋到中山物流公司
乐清到郑州管城区货运专线展会运输_乐清到管城区物流公司
平面磨床的平稳性质量至关重要
青岛到道孚县专线物流[全境派送]_青岛到甘孜道孚县物流货运公司
无锡到重庆渝中区物流专线直达货运,无锡到渝中区物流公司
无锡到沈阳沈北新区专线物流公司_无锡到沈北新区物流公司专线货运
复合板台面六角钳工台
句容到镇江货运专线直达物流_句容到镇江物流公司
慈溪到锦州货运公司,慈溪到锦州物流专线返程车货运
威海到深圳南山区货运专线返程车_威海到南山区物流公司
作者：maheshd.chavanpatil,1aymankhdair,1yogeshpatil,1hiteshhanda,2guangzhaomao,2jayanthpanyam1,3
1departmentofpharmaceuticalsciences,eugeneapplebaumcollegeofpharmacyandhealthsciences,waynestateuniversity,detroit,mi48201
2departmentofchemicalengineeringandmaterialsscience,collegeofengineering,waynestateuniversity,detroit,mi48202
3karmanoscancerinstitute,detroit,mi48201
摘要：poordrugencapsulationefficiencyandrapidreleaseoftheencapsulateddruglimittheuseofnanoparticlesinbiomedicalapplicationsinvolvingwater-solubledrugs.wehavedevelopedanovelpolymer-surfactantnanoparticleformulation,usingtheanionicsurfactantaerosolottm(aot)andpolysaccharidepolymeralginate,forsustainedreleaseofwater-solubledrugs.particlesizeofnanoparticles,asdeterminedbyatomicforcemicroscopyandtransmissionelectronmicroscopy,wasintherangeof40–70nm.weaklybasicmoleculeslikemethyleneblue,doxorubicin,rhodamine,verapamil,andclonidinecouldbeencapsulatedefficientlyinaot-alginatenanoparticles.invitroreleasestudieswithbasicdrugmoleculesindicatethatnanoparticlesreleased60–70%oftheencapsulateddrugover4weeks,withnearzero-orderreleaseduringthefirst15days.studieswithanionicdrugmoleculesdemonstratepoorerdrugencapsulationefficiencyandmorerapiddrugreleasethanthoseobservedwithbasicdrugs.furtherstudiesinvestigatingtheeffectofsodiumconcentrationinthereleasemediumandthechargeofthedrugsuggestthatcalcium-sodiumexchangebetweennanoparticlematrixandreleasemediumandelectrostaticinteractionbetweendrugandnanoparticlematrixareimportantdeterminantsofdrugrelease.inconclusion,wehaveformulatedanovelsurfactantpolymerdrugdeliverycarrierdemonstratingsustainedreleaseofwater-solubledrugs.
关键词：alginate;drugdelivery;controlledrelease;nanoparticles;polyelectrolytes;surfactants
武汉到河间货运专线直达物流_武汉到河间物流公司
湛江到无锡滨湖区物流专线_湛江到滨湖区物流公司直达运输
优质巢湖到上海杨浦区物流公司,专业巢湖到杨浦区物流专线
彭州到中山货运专线家具运输_彭州到中山物流公司
南京到济南市中区专线物流公司[省心派送]_南京到市中区专线货运
90plus 纳米粒度仪应用案例-22
南京到上海松江区货运公司,南京到松江区物流专线返程车货运
无锡滨湖区到北京东城区专线物流货运_无锡滨湖区到东城区物流专线运输公司
专业金华到当雄县物流公司,金华到西藏当雄县物流专线运输
常州到西宁货运公司,常州到西宁物流专线回程车货运
如皋到中山货运专线物流直达_如皋到中山物流公司
乐清到郑州管城区货运专线展会运输_乐清到管城区物流公司
平面磨床的平稳性质量至关重要
青岛到道孚县专线物流[全境派送]_青岛到甘孜道孚县物流货运公司
无锡到重庆渝中区物流专线直达货运,无锡到渝中区物流公司
无锡到沈阳沈北新区专线物流公司_无锡到沈北新区物流公司专线货运
复合板台面六角钳工台
句容到镇江货运专线直达物流_句容到镇江物流公司
慈溪到锦州货运公司,慈溪到锦州物流专线返程车货运
威海到深圳南山区货运专线返程车_威海到南山区物流公司