粪便中的挥发性有机化合物可用于大肠癌的早期检测：我们现在在哪里？
fecal volatile organic compounds for early detection of colorectal cancer: where are we now?
粪便中的挥发性有机化合物可用于大肠癌的早期检测：我们现在在哪里？
bosch s1, berkhout dj2,3, ben larbi i4, de meij tg2, de boer nk4.
1department of gastroenterology and hepatology, amsterdam umc, vrije universiteit amsterdam, ag&m research institute, amsterdam, the netherlands. s.bosch1@vumc.nl.
2department of pediatric gastroenterology, amsterdam umc, vrije universiteit amsterdam, amsterdam, the netherlands.
3department of pediatric gastroenterology, amsterdam umc, university of amsterdam, emma children's hospital, amsterdam, the netherlands.
4department of gastroenterology and hepatology, amsterdam umc, vrije universiteit amsterdam, ag&m research institute, amsterdam, the netherlands.
abstract introduction:
the fecal volatolome, which is composed of fecal volatile organic compounds (vocs), seems to hold potential as non-invasive biomarker for the detection of colorectal cancer (crc) and its precursor lesions advanced adenomas (aa). the potential of the fecal volatolome has been subject of various studies using either chemical analytical or pattern-recognition techniques. the available literature on the potential of the fecal volatolome as crc and aa biomarker was reviewed.
由粪便挥发性有机化合物(voc)组成的粪便挥发物似乎具有作为检测结肠直肠癌(crc)及其前体病变晚期腺瘤(aa)的非侵入性生物标记物的潜力。粪便挥发物的潜力已通过化学分析或模式识别技术进行了各种研究。综述了有关粪便挥发物作为crc和aa生物标志物的潜力的文献。
methods:
a systematic literature search was conducted in pubmed, embase, the cochrane library, google scholar and researchgate using the following keywords: colorectal cancer, advanced adenoma, volatile organic compound, metabolome, gas chromatrography-mass spectrometry, selected-ion flow-tube mass spectrometry, enose, and fecal biomarkers.
在pubmed，embase，cochrane图书馆，google scholar和researchgate中使用以下关键字进行了系统的文献检索：结肠直肠癌，晚期腺瘤，挥发性有机化合物，代谢物组，气相色谱-质谱法，选择离子流管质谱法，enose和粪便生物标志物。
results:
eighty-eight titles or abstracts were identified from the search, of which 11 papers describing the potential of the fecal volatolome for crc detection were selected. in these studies, different techniques were used for the headspace analyses of fecal vocs, limiting the possibility to compare outcomes. increased levels of amino acids and short chain fatty acids, and decreased levels of bile acids and polyol alcohols in the gas phase of feces were observed repeatedly. all selected papers reported high diagnostic value for the detection of both crc and aa based on fecal vocs.
通过搜索确定了88个标题或摘要，其中选择了11篇描述粪便挥发物检测crc潜力的论文。在这些研究中，粪便voc的顶空分析使用了不同的技术，从而限制了比较结果的可能性。反复观察到粪便气相中氨基酸和短链脂肪酸的含量增加，胆汁酸和多元醇的含量下降。所有入选的论文均对基于粪便vocs的crc和aa检测具有较高的诊断价值。
conclusion:
based on the included studies, fecal voc analyses seem promising for future screening of crc and aa, with potentially improved test performances allowing for earlier detection of aa and crc and consequently earlier initiation of treatment, possibly reducing morbidity and mortality rates next to lower rates of (unnecessary) colonoscopies.
根据纳入的研究，粪便voc分析似乎有望用于未来的crc和aa筛查，其测试性能可能得到改善，从而可以更早地检测aa和crc，从而更早地开始治疗，从而可能降低发病率和死亡率，同时降低其发病率。 (不必要的)*检查。
keywords:advanced adenoma; biomarker; colorectal carcinoma; screening; volatile organic compounds
关键词：晚期腺瘤; 生物标志物 大肠癌；筛选；挥发性有机化合物
【PMC-550F】
机床油雾净化器的特点你知道吗
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可燃气体检测仪在现场安装时应注意事项
王研式透气度仪的使用方法，就差你不知道了
粪便中的挥发性有机化合物可用于大肠癌的早期检测：我们现在在哪里？
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多介质过滤器的滤料应该如何选择
说说交直流试验变压器用途和作用
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粪便中的挥发性有机化合物可用于大肠癌的早期检测：我们现在在哪里？
bosch s1, berkhout dj2,3, ben larbi i4, de meij tg2, de boer nk4.
1department of gastroenterology and hepatology, amsterdam umc, vrije universiteit amsterdam, ag&m research institute, amsterdam, the netherlands. s.bosch1@vumc.nl.
2department of pediatric gastroenterology, amsterdam umc, vrije universiteit amsterdam, amsterdam, the netherlands.
3department of pediatric gastroenterology, amsterdam umc, university of amsterdam, emma children's hospital, amsterdam, the netherlands.
4department of gastroenterology and hepatology, amsterdam umc, vrije universiteit amsterdam, ag&m research institute, amsterdam, the netherlands.
abstract introduction:
the fecal volatolome, which is composed of fecal volatile organic compounds (vocs), seems to hold potential as non-invasive biomarker for the detection of colorectal cancer (crc) and its precursor lesions advanced adenomas (aa). the potential of the fecal volatolome has been subject of various studies using either chemical analytical or pattern-recognition techniques. the available literature on the potential of the fecal volatolome as crc and aa biomarker was reviewed.
由粪便挥发性有机化合物(voc)组成的粪便挥发物似乎具有作为检测结肠直肠癌(crc)及其前体病变晚期腺瘤(aa)的非侵入性生物标记物的潜力。粪便挥发物的潜力已通过化学分析或模式识别技术进行了各种研究。综述了有关粪便挥发物作为crc和aa生物标志物的潜力的文献。
methods:
a systematic literature search was conducted in pubmed, embase, the cochrane library, google scholar and researchgate using the following keywords: colorectal cancer, advanced adenoma, volatile organic compound, metabolome, gas chromatrography-mass spectrometry, selected-ion flow-tube mass spectrometry, enose, and fecal biomarkers.
在pubmed，embase，cochrane图书馆，google scholar和researchgate中使用以下关键字进行了系统的文献检索：结肠直肠癌，晚期腺瘤，挥发性有机化合物，代谢物组，气相色谱-质谱法，选择离子流管质谱法，enose和粪便生物标志物。
results:
eighty-eight titles or abstracts were identified from the search, of which 11 papers describing the potential of the fecal volatolome for crc detection were selected. in these studies, different techniques were used for the headspace analyses of fecal vocs, limiting the possibility to compare outcomes. increased levels of amino acids and short chain fatty acids, and decreased levels of bile acids and polyol alcohols in the gas phase of feces were observed repeatedly. all selected papers reported high diagnostic value for the detection of both crc and aa based on fecal vocs.
通过搜索确定了88个标题或摘要，其中选择了11篇描述粪便挥发物检测crc潜力的论文。在这些研究中，粪便voc的顶空分析使用了不同的技术，从而限制了比较结果的可能性。反复观察到粪便气相中氨基酸和短链脂肪酸的含量增加，胆汁酸和多元醇的含量下降。所有入选的论文均对基于粪便vocs的crc和aa检测具有较高的诊断价值。
conclusion:
based on the included studies, fecal voc analyses seem promising for future screening of crc and aa, with potentially improved test performances allowing for earlier detection of aa and crc and consequently earlier initiation of treatment, possibly reducing morbidity and mortality rates next to lower rates of (unnecessary) colonoscopies.
根据纳入的研究，粪便voc分析似乎有望用于未来的crc和aa筛查，其测试性能可能得到改善，从而可以更早地检测aa和crc，从而更早地开始治疗，从而可能降低发病率和死亡率，同时降低其发病率。 (不必要的)*检查。
keywords:advanced adenoma; biomarker; colorectal carcinoma; screening; volatile organic compounds
关键词：晚期腺瘤; 生物标志物 大肠癌；筛选；挥发性有机化合物
【PMC-550F】
机床油雾净化器的特点你知道吗
高周波感应表面淬火优缺点比较
可燃气体检测仪在现场安装时应注意事项
王研式透气度仪的使用方法，就差你不知道了
粪便中的挥发性有机化合物可用于大肠癌的早期检测：我们现在在哪里？
石材雕刻机的主要特点
多介质过滤器的滤料应该如何选择
说说交直流试验变压器用途和作用
传动链条的清洗方法！
氧化安定性测定仪的操作说明（二）
内循环厌氧反应器的优点主要有这些
真空烤箱
河津市硅胶灭火毯一块多少钱
MTS高分辨率磁致伸缩传感器具有较强的抗腐蚀能力
力士乐高频响方向阀4WRTE选型资料REXROTH比例阀现货
电蒸两用乳化机的工作原理
美国华瑞PGM-1850便携式红外二氧化碳检测仪资料
Lika增量编码器 IQ36系列 紧凑而坚固
电缆热补机节能价值提升